Periodic Hematopoiesis in Human Cyclic Neutropenia
نویسندگان
چکیده
منابع مشابه
Periodic hematopoiesis in human cyclic neutropenia.
Human cyclic neutropenia is characterized by severe depression of blood neutrophil levels approximately every 21 days. To investigate the mechanism of cyclic neutropenia four patients were studied with daily complete blood counts, serial bone marrow examinations, marrow reserve testing, serum muramidase determinations, DF(22)P granulocytokinetic studies, and, in one patient, in vivo [(3)H]TdR l...
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Two grey collie dogs had regular cyclic fluctuations in the number of all formed elements of the blood. The period lengths for all elements for an individual dog were the same, but the pattern of fluctuation for each element was distinctive. Normal dogs lacked periodic fluctuations.The patterns of day-to-day variation in the normal dogs counts were consistent with a first-order autoregressive p...
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By BERNARD H. CHAIKEN, CAPT., MC, USAR P ERIODIC (cyclic) neutropeisia is a chrotsic disorder of the blood, characterized by the regular recurrensce of neutrophilic gratsubocytopetsia, at approximately three week itstervals, with secondary constitutiotsal symptoms such as anorexia, malaise, atsd fever, and secotsdary insfectiotss such as stomatitis, pharytsgitis, folliculitis, lymphadetsitis, a...
متن کاملCyclic neutropenia.
Cyclic neutropenia is a rare hematologic disorder, characterized by repetitive episodes of fever, mouth ulcers, and infections attributable to recurrent severe neutropenia. Fluctuations in blood cells are due to oscillatory production of cells by the bone marrow. Recent genetic, molecular, and cellular studies have shown that autosomal-dominant cyclic neutropenia and sporadic cases of this dise...
متن کاملCyclic neutropenia in mammals.
Cyclic neutropenia (CN) has been well documented in humans and the gray collie. A recent model of the architecture and dynamics of hematopoiesis has been used to provide insights into the mechanism of cycling of this disorder. It provides a link between the cycling period and the cells where the mutated ELA2 is expressed. Assuming that the biologic defect in CN is the same in dogs, and the obse...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1973
ISSN: 0021-9738
DOI: 10.1172/jci107522